Abstract

The gas chromatography-mass spectrometry (GC-MS) analysis of the methanolic extract of the Anabaena species identified a diverse range of bioactive compounds, with propanedioic acid (5.96%), benzoic acid (2.22%), and phenol, 2,6-dimethoxy- (2.11%) being the most abundant. The α-amylase enzyme inhibition assay demonstrated a concentration-dependent effect, with inhibition rates increasing from 14.69% at 10 μg/ml to 70.36% at 50 μg/ml, suggesting its potential for managing postprandial hyperglycemia by slowing carbohydrate digestion. The 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay for cytotoxicity on normal cell lines revealed that MCF-10A viability decreased from 96.46% at 25 μg/ml to 52.36% at 200 μg/ml, while L929 cell viability declined from 94.64% to 60.69% over the same concentration range. These results indicate that Anabaena species methanol extract exhibits significant bioactivity, with promising applications in pharmaceuticals and nutraceuticals, warranting further studies to validate its therapeutic potential.

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