Exploring the Therapeutic Potential of Dandelion Phytochemicals in Cancer Prevention

Sham Su Zuha and Jaspreet Kaur

Abstract

Cancer remains a significant global health challenge, necessitating the exploration of innovative therapeutic strategies. Apoptosis, a programmed cell death mechanism, plays a crucial role in maintaining tissue homeostasis and preventing the uncontrolled proliferation of damaged or malignant cells. Dandelion has attracted substantial attention due to its purported anticancer properties through apoptosis. These mechanisms encompass the activation of death receptor pathways, modulation of mitochondrial function, interference with survival signaling pathways (such as PI3K/Akt and NF-κB), and the regulation of pro-apoptotic and anti-apoptotic proteins. Furthermore, the intricate crosstalk between dandelion phytochemicals and immune responses, as well as their potential synergy with conventional cancer therapies, is elucidated. The key preclinical and clinical studies investigating the apoptotic effects of dandelion extracts, individual phytochemicals (sesquiterpene lactones, flavonoids, and polyphenols), and their formulations are critically analyzed. The diversity of cancer models, experimental conditions, and methodologies utilized in these studies are examined to provide a comprehensive understanding of the reproducibility and translational potential of the reported findings. This review provides a thorough examination of the current state of knowledge regarding dandelion’s potential in cancer treatment, offering insights into its mechanisms of action, key findings from studies, and outlining essential objectives for future research in this promising field.

Published on: November 15, 2023
doi: 10.17756/jfcn.2023-s1-062
Citation: Zuha SS, Kaur J. 2023. Exploring the Therapeutic Potential of Dandelion Phytochemicals in Cancer Prevention. J Food Chem Nanotechnol 9(S1): S490-S497.

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