Preliminary Phytochemical Screening and Determination of Anxiolytic, Analgesic, and Antibacterial Potentials of a Medicinal Plant – Alpinia conchigera Griff

Rajkumar Roy, Fahomida Hassan, Sahid Ahmad Santo, Md Sohel, Mahmuda Ferdous, Mohammad Sarowar Uddin, Md Nasim Uddin, Mohammad Safiqul Islam, Md. Saqline Mostaq, Mohammad Nurul Amin and Md. Shalahuddin Millat

 

Abstract

People in rural areas are using several traditional medicinal plants to make a inntial treatment against numerous diseases. Antibacterial activity of methanolic Alpinia conchigera Griff rhizomes extracts’ was determined in vitro study through the disk diffusion method. The anxiolytic activity was tested on Swiss albino mice using both open field and hole cross methods, while analgesic activity was assessed via formalin-induced hind paw licking test and acetic acid-induced writhing test in mice. There was a wide spectrum of phytoconstituents found during the phytochemical screening process. The rhizome extract possesses moderate antimicrobial activity against gram-positive bacteria but is resistant to gram-negative bacteria. The rhizome extract significantly reduced locomotor activity of mice in an open field and hole cross methods in a dose-dependent manner (100, 200, and 400 mg/kg) compared to standard drugs diazepam (1 mg/kg). Acetic acid-induced writhing in mice was considerably (p<0.05) reduced by plant extracts at 29.11%, 35.44%, and 48.10% at 100, 200, and 400 mg/kg, respectively, compared to acetylsalicylic acid (standard drug) with 51.89%. 200 and 400 mg/kg of rhizomes extract provided positive results in formalin-induced hind paw licking test by 45.38% to 61.00% at an early phase and 62.50% to 69.70% at late phase, respectively, whereas aspirin (100 mg/kg) revealed 29.23% and 39.28% of inhibition at both phases sequentially. To recapitulate, the experimental can be used as traditional medicine against numerous diseases, but further studies are necessary to validate this plant extract as a drug.

Published on: May 23, 2023
doi: 10.17756/jfcn.2023-150
Citation: Roy R, Hassan F, Santo SA, Sohel M, Ferdous M, et al. 2023. Preliminary Phytochemical Screening and Determination of Anxiolytic, Analgesic, and Antibacterial Potentials of a Medicinal Plant – Alpinia conchigera Griff. J Food Chem Nanotechnol 9(2): 47-53.

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